GL10

Seasonal trends in the timing of TB diagnoses have been noted at different latitudes. Differences in clinical phenotypes have been described by lineage, largely on the basis of single-country studies. With the accumulation of whole-genome sequencing data we have new opportunities to revisit old epidemiological questions at the local level through transmission studies and at the global level through data sharing. I will present data from two studies that offer some new insights into TB transmission dynamics, and into the clinical manifestations of ancient versus modern lineages.