P062

1:IAME, UMR1137 INSERM-Université Paris-Cité, Université Sorbonne Paris-Nord; 2:Université de Franche-Comté; 3:Université Paris-Saclay

Lineage 1 is an ancestral Lineage of Mycobacterium tuberculosis complex (MTBC)  made up of at least five sublineages. In a previous study, we suggested that the introduction of a representative of  the L1.1.3 sublineage of Lineage 1 found both in Mozambique and in the North of Brazil could have been brought to Brazil through maritime route during the long-term slave history that lasted from the early XVIth to the mid XVIIIth century between Africa and Brazil. In this study, thanks to combination of bacterial genomic and historical human migration data, we reconstitute scenarii of introduction of L1 genotypes from two likely origins in Africa: West Africa (current Angola or Congo region) and/or East-Africa (Mozambique). We present results showing important similarities between population structure of MTBC in Mozambique and in Brazil and suggest that multiple introductions during the XVIth to the XIXth century period could indeed explain the contemporaneous observations of L1 MTBC tuberculosis cases in Northern-Brazil, due to transmission within Brazil after these historical forced slave migrations.