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Unlocking the potential of phylodynamic birth-death models: Opportunities and challenges in TB epidemiology

E Windels(1)

1:ETH Zürich, Basel

Over the past years, the TB field has seen an explosion of genomic sequencing data. These data not only yield insights into which strains are circulating where, but also contain detailed information about past Mtbtransmission dynamics, including transmission rates, reproductive numbers, and duration of infectiousness. Phylodynamic methods provide an efficient and accurate way of extracting this information, but have so far seen limited use in the field. In this talk, I will focus on phylodynamic birth-death models, showcase their potential for Mtb transmission studies, and highlight Mtb-related challenges.


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