Sunday 26 June
12:30-14:30
Registration
14:30-16:00
Workshop on blood signatures/transcriptomics as biomarkers
Chairs: Iñaki Comas, Instituto de Biomedicina de Valencia (CSIC); Daniela Maria Cirillo, San Raffaele Scientific Institute, Milan
OR01 Francesca Saluzzo, Vita-Salute San Raffaele University
Looking for early treatment response biomarkers in TB platform trials: the EU-PEARL experience
GL01 Delia Goletti, Istituto Nazionale Malattie Infettive L. Spallanzani ⓘ
Biomarkers for TB infection: past, present and future
GL02 Yohhei Hamada, University College London ⓘ
Are mRNA based transcriptomic technologies mature enough to develop next-generation in-vitro diagnostic tests for tuberculosis? – A review of evidence and the technology landscape
GL03 Norbert Hittel, Otsuka Pharmaceutical ⓘ
LAM in sputum as a biomarker in clinical trials
16:00-16:30
Coffee break
16:30-19:00
Opening session
Chairs: Daniela Maria Cirillo, San Raffaele Scientific Institute, Milan; Stefan Niemann, Forschungszentrum Borstel
Daniela Maria Cirillo, San Raffaele Scientific Institute, Milan and Tizziana Lazzarotto, Director of the Microbiology ward, Bologna
Welcome
GL04 Opening keynote:
Marina Tadolini, University of Bologna - WHO GTB consultant ⓘ
Unexpected challenges to end tuberculosis
GM Award presented by Stefan Niemann
GL05 Gardner Middlebrook Awards 1 presented by BD
GL06 Gardner Middlebrook Awards 2 presented by BD
Award Ceremony 2021
19:00
Welcome reception
Monday 27 June
08:00-09:00
Registration
09:00-10:30
Host-pathogen interaction
Chairs: Paolo Miotto, San Raffaele Scientific Institute, Milan, Iñaki Comas, Instituto de Biomedicina de Valencia (CSIC)
GL07 Marcel Behr, McGill ⓘ
Revisiting the timeline of TB: beyond latent and active TB
GL08 Kristine Arnvig, University College London ⓘ
Sensing and adapting with RNA in Mycobacterium tuberculosis
OR02 Stefano di Giorgi, University of Padova
Ex vivo human model of TB based on Granuloma-like Structure (GLSs) to evaluate the efficacy of drugs
OR03 Christian Utpatel, Research Center Borstel
Diversity of Mycobacterium tuberculosis complex Lineage 1 - phylogeography, sub-lineages and their associated phenolic glycolipid patterns
10:30-11:00
Coffee break
11:00-12:45
Transmission/Evolution of TB complex
Chairs: Matthias Merker, Research Center Borstel; Arash Ghodousi, Università Vita-Salute San Raffaele
GL09 Sébastien Gagneux, Swiss Tropical & Public Health Institute ⓘ
Ecology and evolution of MDR M. tuberculosis
GL10 Timothy Walker, University of Oxford ⓘ
The effects of season and lineage on TB: old questions, new insights?
OR04 Matthias Groeschel, Harvard Medical School
Host-pathogen co-adaptation shapes susceptibility to infection with M. tuberculosis
OR05 Maximilian Marin, Harvard Medical School
Long read sequencing reveals gene conversion as a diversity generating mechanism in Mycobacterium tuberculosis
OR06 Carla Mariner Llicer, Instituto de biomedicina de valencia (CSIC)
Comparison of Mycobacterium tuberculosis genetic variability within sputum-culture paired samples in different settings: Mozambique and Georgia
12:45-13:45
Lunch
13:45-14:45
Poster session day 1
14:45-16:00
Covid and TB
Chairs: Emmanuelle Cambeau, Université de Paris, Inserm UMR 1137 IAME; Stefan Niemann, Forschungszentrum Borstel
GL11 Troels Lillebaek, Statens Serum Institute ⓘ
From MTB to SARS-CoV-2 molecular epidemiology, experiences from Denmark
GL12 Iñaki Comas, Biomedicine Institute of Valencia (IBV) ⓘ
TB and COVID-19: two sides of the same coin?
OR07 Dario Garcia de Viedma, Instituto de Investigación sanitaria Gregorio Marañón. Madrid
Tuberculosis along the pandemic: Molecular and genomic epidemiology to analyze changes in general dynamics and reinterprete relevant transmission clusters
16:00-16:30
Coffee break
16:30-18:00
Molecular diagnostic
Chairs: Leen Rigouts, Institute of Tropical Medicine, Antwerp; Andrea Cabibbe, San Raffaele Scientific Institute, Milan
GL13 Stefan Niemann, Forschungszentrum Borstel ⓘ
Targeted genome sequencing of drug resistant tuberculosis: a laboratory perspective
OR08 Claudio Köser, University of Cambridge
Lineage 1 is the odd one out for pretomanid and pyrazinamide – implications for antimicrobial susceptibility testing and treatment
OR09 Amandine Sury, Sciensano, Brussels
Phenotyping resistance to new and emerging medicines by a fast RNA‑based drug susceptibility test
OR10 Christian Chukwuezugo Otum, Stellenbosch University
Site-directed mutagenesis of Mycobacterium tuberculosis and functional validation to investigate potential bedaquiline resistance causing mutations
OR11 Teresa Walz, Research Center Borstel
Mycobacterium tuberculosis complex bacteria adaptation to antibiotics: Evolution informed tuberculosis treatments
19:00-Midnight
Congress party
Palazzo Isolani (Corte Isolani 5, 40125 Bologna)
Tuesday 28 June
08:30-09:00
Registration
09.00-10.30
New diagnostic strategies
Chairs: Elisa Tagliani, San Raffaele Scientific Institute, Milan; Leen Rigouts, Institute of Tropical Medicine, Antwerp
GL14 Morten Ruhwald, FIND ⓘ
Update on the TB diagnostic pipeline, a response to the impact of the covid-19 pandemic
OR12 Viola Dreyer, Research Center Borstel
Rapid molecular diagnostics of resistance tuberculosis by targeted stool sequencing
OR13 Faridath Massou, Supranational Reference Laboratory for Tuberculosis, Cotonou
Multicentre evaluation of Xpert XDR and TrueNat 2nd line tests under field conditions
OR14 Leonardo de Araujo, Research Center Borstel
Collaborative implementation of targeted next-generation sequencing for the diagnosis of drug-resistant tuberculosis in Eswatini.
OR15 Julian Libiseller-Egger, London School of Hygiene and Tropical Medicine (LSHTM)
A standard and framework to facilitate the comparison and benchmarking of methods for resistance prediction from genomic data
10.30-11.00
Coffee break
11:00 - 12:00
MDR TB
Chairs: Daniela Maria Cirillo, San Raffaele Scientific Institute, Milan; Matthias Merker, Research Center Borstel
OR16 Rita Sorrentino, San Raffael Scientific Institute
Role of smallRNAs in rifampicin tolerance in M. tuberculosis complex
OR17 Diana Machado, Instituto de Higiene e Medicina Tropical, IHMT, Universidade Nova de Lisboa, UNL, Lisboa,
Efflux-mediated pretomanid high-level resistance in Mycobacterium tuberculosis
OR18 Galo Goig, Swiss Tropical and Public Health Institute
Transmissibility of drug-resistant tuberculosis in a high-endemic setting as explained by bacterial genetic epistasis
12.00-13.00
Vaccine
Chairs: Troels Lillebaek, Statens Serum Institut, Copenhagen; Iñaki Comas, Instituto de Biomedicina de Valencia (CSIC)
GL15 Frank Cobelens, Amsterdam Institute for Global Health and Development (AIGHD) ⓘ
Tuberculosis vaccine development: accelerate!
OR19 Pere-Joan Cardona, Hospital Universitari Germans Trias i Pujol. IGTP
Immunotherapy with RUTI vaccine, a new universal tool to improve the chemotherapy in active tuberculosis
OR20 Julia Figl, Friedrich-Loeffler-Institut, Institute of Molecular Pathogenesis, Jena
Efficacy of recombinant BCG vaccine candidates against Mycobacterium bovis infection in goats
13.00-14.00
Lunch
14.00-15.00
Poster session day 2
15.00-16.00
Non tuberculosis mycobacteria
Chairs: Nicola Lore, San Raffaele Scientific Institute, Milan; Sebastien Gagneux, Swiss Tropical & Public Health Institute
GL16 Jakko van Ingen, Radboud University Medical Center, Nijmegen ⓘ
The future of NTM treatment: PK/PD and EUCAST susceptibility testing
OR21 Nicola Lore, San Raffaele Scientific Institute
Unravelling the pathogenicity of Mycobacterium abscessus clinical isolates in CF pulmonary epithelial cell and mouse models of respiratory infection
OR22 Margo Diricks, Research Center Borstel
Delineating Mycobacterium abscessus population structure and transmission employing high-resolution core genome multilocus sequence typing
16.00-16.30
Coffee break
16.30-17.30
General Assembly
18.00-20.00
Guided tour of the city
20.00-23:00
Traditional dinner
Cantina Bentivoglio (Via Mascarella 4/b, 40126, Bologna)
Wednesday 29 June
09:00-09:30
Registration
09.30-11.00
New Policies
Chairs: Andrea Cabibbe, San Raffaele Scientific Institute, Milan; Bouke de Jong, Institute of Tropical Medicine, Antwerp
GL17 Daniela Maria Cirillo, San Raffaele Scientific Institute, Milan ⓘ
Summary of the new policies
GL18 Paolo Miotto, San Raffaele Scientific Institute, Milan ⓘ
The WHO catalogue of mutations in M.tuberculosis and associated drug resistance
GL19 Emmanuelle Cambau, Université de Paris, Inserm UMR 1137 IAME ⓘ
New standards on sensitivity testing
11.00-12.00
Coffee break
12.00-12.45
Closing lecture
Chairs: Daniela Maria Cirillo, San Raffaele Scientific Institute, Milan; Silva Tafaj, University Hospital "Shefqet Ndroqi", Tirana
GL20 Vanni Bucci, UMass Chan Medical School ⓘ
Microbiome dynamics and peripheral immune renormalization during anti-Mtb treatment